Currently, there is a big difference in the initial condition and development environment between the enterprises created by the migrant workers returning-to-hometown in the less-developed area in middle and west areas of China and the private economy at costal areas at the initial time of reform and opening-up, as a result, the industrial development direction for the enterprises created by the migrant workers returning-to-hometown should be clarified according to their post-development advantage and post-development disadvantage. The majority of these enterprises are staying at infant and weak period and in high risk stage in their initial entrepreneurship time and have the vulnerable characteristics such as high failure rate, high new increase rate, short life cycle and weak competence. The main factors to limit the viability and development of these enterprises are insufficient entrepreneurship capital, small enterprise scale, low level, short of management talents and skilled workers, and inadequate industrial correlated matching support. Meanwhile, the utility of supporting policies for these enterprises is weakened by insufficient policy and administration integration, short time effect, low covering degree and so on. Thus, China should enlarge the capital support to these enterprises, consolidate investment guidance and industrial classification and segmentation guidance, strengthen administrative integration, change support policy from short-term to sustainability, and enlarge the beneficial areas from the support policies.