The key to promoting the systematic research and academic interpretation of Xi Jinping Thought on Culture lies in accurately grasping its Defining Concepts. Defining Concepts are not only a high-level summary of the scientific system but also an important symbol distinguishing it from other ideological systems. As a Defining Concept of Xi Jinping Thought on Culture, the “Two Combinations” fully embodies the world outlook and methodological stance, original theoretical contributions, and unique ideological formation field in this thought. To uphold the fundamental requirements of the “Two Combinations”, it is essential to advance the research and elucidation of Xi Jinping Thought on Culture with a focus on its systematization and academic formalization. Furthermore, we must promote the construction of an independent knowledge system for Chinese philosophy and social sciences, thereby continuously enriching and developing the new form of human advancement.