New quality productive forces empower comprehensive rural revitalization with their characteristics of “high innovation, high-quality, and high-efficiency”, and have become an important engine for promoting high-quality rural development. Based on the analysis of the concept of new quality productive forces, this study constructs an analytical framework for new quality productive forces to empower comprehensive rural revitalization. It is found that the mechanism of new quality productive forces empowering comprehensive rural revitalization is mainly manifested in the following aspects: empowering rural industrial revitalization through scientific and technological innovation; promoting rural talent revitalization through the cultivation of new-quality talents; promoting rural cultural revitalization through digital empowerment; driving rural ecological revitalization with green productivity; and promoting rural organizational revitalization through intelligent rural governance. To realize the empowerment of comprehensive rural revitalization by new quality productive forces, it is necessary to strengthen the cultivation of new-quality talents, attach importance to the development of new-quality means of labor, accelerate the exploration of new-quality labor objects, and enhance the synergy among the elements of new quality productive forces.