By analyzing the keywords of high-level academic papers in educational informatization, we can reveal the hot topics and the development trend of educational informatization, which has far-reaching significance for the research and the development of educational informatization in China. Based on the educational informatization literature in the CSSCI database in the past decade, a high frequency keyword co-word matrix was constructed and the co-word network was generated. Co-word analysis, social network analysis, strategic diagram analysis, and other methods were used to identify and analyze the development trend and hot topics in education informatization in China. Research shows that: MOOC, artificial intelligence, instructional design, and deep learning have received extensive attention from education researchers; current educational informatization research mainly focuses on learning analysis, online learning and open education, informatization teaching models and methods, educational informatization theory and practice, teacher professional development, learning environment and learning resources, and other topics, and the learning analysis of online learning is currently the most active research topic and has achieved fruitful results.