Micro-blog and We-chat, as today’s the most rapidly developed social communication network products, become the indispensable communication software of human beings. By using questionnaire on micro-blog and we-chat users, mainly on college students, by statistically analyzing the data of the questionnaire, based on the previously related conclusions in the literatures and theories, this paper analyzes the factors affecting the using willing of micro-blog and we-chat users, and tests the difference in the users’ application of two kinds of software. Comparison and analysis results show that the main difference of micro-blog and we-chat lies in the users’ demand of different factors such as social communication method, entertainment method, business activity, new information acquirement and so on. Thus, future micro-blog and we-chat development channel will mainly depend on users’ practical demand to be perfected so that the users’ demand will be satisfied and that social communication software will be improved.