Questionnaire is used to survey interpersonal trust, social support and interpersonal communication of the students in part of colleges and universities in Fujian Province, and the results show that the influence of interpersonal trust, social support and interpersonal communication on single child is not significant, that the impact of gender on interpersonal trust and social support is significant, that the effect of major on social support is obvious, that the influence of grade, family residing place and parent profession on interpersonal trust, social support and interpersonal communication is significant, that there is close relation among interpersonal trust, social support and interpersonal communication of college students, and that regression analysis indicates that general trust, subjective support and the utilization of support can predict the interpersonal communication of college students, which reveals that interpersonal trust and social support are important factors to affect interpersonal communication in college students.