In order to have a deeper understanding of the unique dendrobine-type alkaloids of Dendrobium Sw， and the biosynthetic pathway of its representative component dendrobine, in this paper， the structures and pharmacological activities of dendrobine-type alkaloids and the biosynthesis of dendrobine were reviewed， and a pathway of dendrobine biosynthesis， which is mainly secondary metabolites of Dendrobium nobile Lindl. was speculated.The number of reported dendrobium alkaloids is 31， derived from 9 species of Dendrobium Sw， and its pharmacological activities are mainly in anti-tumor， anti-cataract， and hypoglycemic aspects. However， the biosynthesis of dendrobium is in the initial stage of research， and only the MVA pathway and 7 related genes have been identified.Finally， it provides three entry points for the in-depth study of dendrobine biosynthesis research：first， we can use farnesyl pyrophosphate (FPP) as the substrate to obtain possible intermediates by the enzymatic reaction； secondly， we can also add FPP to the culture medium of D. nobileLindl.tissue culture seedlings to promote the possible intermediates； thirdly， we can start with the accumulation characteristics of dendrobine， find the point with the most intermediates and carry out the separation of the possible intermediates.