In view of the problems of system documents, index system, internal audit management, standardpassing management and resultbased management in the process of promoting the Informatization and Industrialization management,such as wideranging work, many links and complex indicators, it is proposed to guide staff to carry out the Informatization and Industrialization Management efficiently by developing an information system. Through the analysis of management requirements of Informatization and Industrialization Management and the development of information system, the staff carries out the Informatization and Industrialization Management by using the system.The system realizes the standardized management of documents, internal audit process, project implementation process and new capacity indicators, integrates and simplifies the collection channels of system documents and basic resources of internal audit standards, and ensures the uniqueness of data sources.Informatization and Industrialization Management Information System realizes the integration of online and process management, unifies the information collection channels and data sources, and guides the staff to carry out the integration management efficiently, which can effectively improve the management level of enterprise Informatization and Industrialization Management.