Abstract:Glucosinolates are found in many dietary plants, including cruciferous vegetables such as broccoli, cabbage, brussels sprouts, and cauliflower.Their derivatives (sulforaphane and phenethyl isothiocyanate et al) can inhibit or reverse the oncogenes during cancer progression.These include activation of II phase detoxification enzyme/antioxidant enzyme, blockage of the inflammatory mediators, induction of tumor suppressor, pro-apoptotic, antioxidant and anti-inflammatory genes through modulating signaling pathways and epigenetic alterations by their interactions with targets in the cells.In this review, we summarize the antitumor activities of the dietary glucosinolate derivatives as inhibitors of carcinogenesis, with particular emphasis on their specific molecular targets.Their cancer chemopreventions were mainly expounded so as to remind people to increase awareness of the prevention of diseases such as cancer.