Under the background of “mass entrepreneurship and innovation”，the college students innovation and entrepreneurship education and its evaluation research are analyzed Then the key factors and assessment models are given which influence the cultivation of college students innovative and entrepreneurial ability Firstly，a combined evaluation model for selecting the right weights is proposed which combined the main advantages of analytic hierarchy process and entropy method Secondly a comprehensive evaluation model of the college students innovation and entrepreneurship based on genetic neural network is established Simultaneously the weight values obtained by the combined weight model are used to adjust the connection weights of the genetic neural network Finally，the validity of this combination evaluation model is verified by the data of an application-style university The project provide a new research idea for the application-style of innovation and entrepreneurship of application-style college students