With respect to the study of nonlinear partial differential equations （PDEs） with variable coefficients，a new method for solving the conservation laws of nonlinear PDEs is proposed.By studying the generalized HirotaSatsuma equations with variable coefficients，we use Lie group analysis method to get the Lie point symmetries，and prove that the system is nonlinearly selfadjoint，namely Ibragimovs theorem，thus construct the general conservation law formula.Then its equivalence transformation which is a nondegenerate point transformation is used in the augmented space to obtain the equivalence algebras.Since the conservation law formula involves in any arbitrary elements，we can draw an infinite number of the conservation laws.