To research the effect and mechanism of personal longterm power sence on negotiation outcome, enrich and innovate existing negotiation theories, a multiissue negotiation was designed and implemented for the subjects. Taking longterm power sence, the first offer and regulatory focus as independent variable, intervening variable and moderating variable, this paper explores the influence of longterm power sence on negotiation outcome, the mediating is of the first offer and regulatory effect of regulatory focus. Main conclusions are: the longterm power sence has a significantly positive correlation with negotiation outcome, the first offer plays a mediating role in the influence of longterm power sence on negotiation outcome, but there is no significant regulatory effect of regulatory focus between longterm power sence and negotiation outcome. Based on above research, negotiator with higher longterm power sence will give a higher first offer, thus get better negotiation income. Regulatory effect of regulatory focus remains to be further explored in future research.