To observe the clinical effects of the new nursing intervention technology on the protection of perianal skin caused by ICU fecal incontinence patients. Methods: For control group one, routine nursing methods were used, i.e. the patients were placed baby diapers and cotton pads, then feces should be cleaned; clothing, quilts and cotton pads should be changed, and perianal skin should be cleaned for the patients whenever necessary. For control group two, the nursing method of tampon or tracheal catheter was solely used. For observation group, based on different types of fecal incontinence patients, different nursing procedure and different nursing intervention technology were selected to protect perianal skin. Results: The rate of perianal skin damage for the observation group is 2.78%, which is apparently lower than control group one and control group two. The difference was statistically significant (P<0.01, χ2=15.23). Conclusion: The selection use of different nursing procedure and different nursing intervention technology based on different types of fecal incontinence patients can reduce the rate of perianal skin damage and nursing cost, which deserves to be popularized in clinical nursing.