With high nutritional value of orange juice, honey, sugar, citric acid as flavoring, chicken polypeptide from a protease enzyme complex is formulated into bone polypeptides drinks with moderate sweet and sour, good smell and light yellow color. The optimal health drink formula and stabilizers formula are explored and perfumer are added into the nutritional drinks. The optimum formulation and stabilizer formula results are 12.00% orange juice, 2.30% honey, 0.11% citric acid, 5.50% sucrose, 0.12% stabilizer compound βcyclodextrin and 0.11%(CMCNa) carboxymethyl sodium carboxymethylcellulose and 0.40% vanilla flavoring. The polypeptide drinks with unique flavor, sweet and sour taste, good stability, functionality have the dual effect of nutrition and health, and quality indicators are in line with national standards. There are great market application and development prospects.