Chongqing, as an economic center at the upper reaches of Yangtze River and an inland economic open height, has stronger radiating and influencing capacity on its neighboring areas, therefore, industrial agglomeration plays a special role in industrial structure transition and upgrading as well as economic development of Chongqing. This paper calculates the influence of industrial agglomeration on Chongqing’s economic development and advances the related measures according to the analysis results by taking Chongqing’s transportation equipment manufacturing industry agglomeration as the research object and by using 1999-2011 statistical data as well as by using regional entropy and econometrics model.