Abstract: Practice is the importment part ofMCU course, firstly, this paper analyzes the current situation of experimental teaching ofMCU course. Secondly, two software: Keil and Proteus are introduced and combined to the simulation experiment ofMCU, so as to imp rove the effect of experimental teaching ofMCU, bring up experimental skills and ability of the students to innovate. They have many traits suche as abundant electronic components, the third party software editor supported, powerful capabilities to draw schematic and abundant system resource, more cheaper and visualized hardware and so on. Finally, good results of simulation experiment are p roved in the teaching reform of experimental teaching ofMCU, through the simulation effect of the examp le of lantern cycle.