In order to improve the profile quality of precision milling of aero-engine blades, a milling process parameter adjustment method based on material removal was proposed.First of all, this paper designs the blade milling process parameter adjustment overall scheme, the development of the blade milling processing overall scheme and process parameter adjustment scheme.Secondly, based on the neural network algorithm, a model for predicting the material removal amount of blade milling was established to evaluate the milling stability of different process parameters.Then, the process parameters were adjusted based on the material removal amount to improve the stability of the milling process, and the optimal combination of process parameters was selected for the blade milling experiment.Finally, CMM was used to detect the blade profile after milling. The experimental results showed that the machining allowance of the blade basin and blade back after milling was distributed within ±005 mm, which met the process requirements. The stability of the material removal model and the correctness of the proposed process parameter adjustment method were verified.