According to the investigation and analysis of the current situation of innovation and entrepreneurship education for students majoring in visual communication design in Chongqing universities, there are some problems, such as imperfect training mechanism, insufficient emphasis on the pertinence and timeliness of economic development in some universities, lack of awareness and ability of teachers to carry out innovation and entrepreneurship education, weak innovative consciousness of college students, and lack of entrepreneurial skills. In view of the lack of innovative thinking, this paper puts forward the concept of trans-disciplinary training of visual communication design professionals and the multi-cooperation mode of practice system. Aiming at the business practice of students majoring in visual communication design of "visual system design of Chongqing characteristic handmade creative products" and the integrated service of related platforms, this paper constructs the training mechanism of visual communication design talents'cross-border education characteristics, perfects the incentive mechanism of entrepreneurship practice projects, and implements the inter-professional and inter-disciplinary collaborative training of school-enterprise research. The mechanism and the implementation of the professional and technical job identification mechanism of entrepreneurial teachers are more suitable for the way of innovation and entrepreneurship development of professional talents. The research proves that only by continually exploring the deep integration of disciplines, precise grafting of specialties, and collaborative education between schools, enterprises and research institutes, can we cultivate new talents, create a harmonious and shared environment of double-creation, and promote the development of innovation and entrepreneurship education of visual communication design specialty in colleges and universities.