The building electromechanical engineering pipeline seismic support is a kind of non-structural component. According to that seismic support can effectively protect building mechanical and electrical equipment engineering facilities in earthquake, making the loss of secondary disasters significantly reduced, the simulation analysis was produced by using the multi-degree-of-freedom system vibration model. The 3-D model, which based on DN series pipeline and common single-tube clamp type hoop lateral seismic brace, was built. The multi-degree-of-freedom system vibration model was studied. By using mode-superposition response spectrum method, the simulation analysis was carried out to extract the modal cloud and seismic displacement response cloud of the pipeline system under different conditions. The simulation results show that the single-tube DN100 can effectively mitigate the seismic displacement response under the constraint of clamp type hoop lateral seismic brace.This method provides a theoretical basis for the design of seismic system of non-structural component, and also provides reference for judging the cumulative damage of non-structural component.