In order to study the evacuation under the disaster of multi-story buildings, taking a multi-story experimental building as the research background, a perceptual model of evacuation is proposed based on multi-agent technology; A disaster scene was built based on a multi-story experimental building, the evacuation model obtains useful information through perceptual ability and make corresponding escape choices according to its own attributes. In addition, the study and discussion of elevator as a supplementary means to participate in evacuation is also added; The experiment simulates the opening and closing of different escape exits to obtain escape data, and the results show that this evacuation model can more realistically demonstrate the status in the catastrophe environment. Through experiments, it is found that this evacuation model is of great help to the study of evacuation in multi-story building disasters, and can also provide the theoretical basis for the assessment of building’s evacuation capacity.