Quality evaluation of graduation design should be objective, fair and accurate. For the existing problems of reply grade evaluation of graduation design for engineering majors, the evaluation index system of reply grade of graduation design is established, including quality of graduation design, presentation skills, ability to respond as well as reply preparation and attitudes. In addition, the weight determination method based on entropy weight and AHP (Analytic Hierarchy Process) is proposed to establish the evaluation model of reply grade of graduation design for engineering majors based on entropy weight and AHP. Finally, the proposed method is illustrated in the graduation design for major of mechatronic engineering.