Based on the meteorological station data and DEM data of Chongqing, this paper firstly estimates global spatial autocorrelation of rainfall in Chongqing by using spatial autocorrelation coefficients; then estimates autocorrelation of local spatial rainfall by using local indicators of spatial association; finally, investigates the spatial distribution of rainfall in Chongqing by using four kinds of interpolation methods Inverse Distance Weighted, Kriging, the method of Splines and the CoKriging.Spatial autocorrelation analysis shows that Chongqing annual rainfall space distribution on the whole presents strong positive correlation, and local spatial autocorrelation analysis shows that there is different dependence degree of rainfall space in different areas in Chongqing.CoKriging interpolation results superior to other spatial interpolation method, based on which the best rainfall simulation results are obtained.