Based on Excellent Engineer Cultivation ideas and the analysis of mechanical principle and the status quo of design course, this paper conducts the research and practical application of comprehensive design for mechanical basic course teaching contents and course system, sufficiently makes use of computer-aided design through using software by thoroughly using computer in the whole course design and teaching links so that course design quality is improved and realizes simplification of complex problems, intuition processing of abstract problems, dynamic processing of static problems, direct processing of indirect problems and practical processing of theoretical problems.