The construction of Longteng Bridge on the second-rank road between Longling and Tengchong in Yunnan Province used pre-stress concrete continuous box girder layout, the span of this bridge is 58m+102.25m+63m,the bridge construction site is located in eight degree seismic area,as a result,the design of the bridge should consider earthquake-resistance.Based on design objective of earthquake-resistance principle,earthquake-resistance analysis under the action of earthquak is conducted including natural vibration characteristics analysis,response spectrum analysis and dynamic time-history analysis,which provides the clear basis for reasonable structure earthquake-resistance design.