Abstract: Over2exp ression of human telomerase reverse transcrip tase ( hTERT) holds a critical role in the de2 velopment of tumor from normal cells. So, those genes and cytokine, which can enhance the exp ression of hTERT, might be involved in the p rogress of tumor development. At p resent, we want to summarize the researching develop2 ment of these factors and theirmechanism, and generally introduce their app lication in tumor therapy targeting on hTERT. Focusing on its functional connection with endogenous factor and its cell factor in tumor physiology and pa2 thology is the direction for further research.