Abstract: There are a variety of ep ilep tic animalmodels such as kindling ep ilep tic modelswith electrostimulation, chemical kin2 dling ep ilep tic models and inherited ep ilep tic models. Most of them are intractable ep ilep sy animal models and are useful for researc2 hing intractable seizure and screening effective drugs. This paper reviewsmakingmethods of different ep ilep tic models, their symp toms and pathogenesis and so on.