| 摘要: |
| ROS/RNS是人类正常代谢的产物,有重要的生理活性,但高浓度时会产生氧化应激,引起癌症、
心血管与肺部、高血压、神经退行性、糖尿病、呼吸道感染、类风湿性关节炎、白内障等氧化损伤疾病。 为了预
防疾病,促进健康,结合大量文献,概述了人体 ROS / RNS 来源及与疾病的关系。 介绍了常见食物抗氧化剂
如酚类化合物、维生素 E、类胡萝卜素及维生素 C 等,探讨了不同结构的抗氧化物质清除自由基、抗氧化机
制。 酚类化合物是人类饮食中广泛存在的抗氧化组分,β-类胡萝卜素为维生素 A 原,维生素 E 为脂溶性、断
链抗氧化剂,能保护细胞膜的完整性。 维生素 C 为水溶性,其自由基歧化速度远高于与其他生物分子如蛋
白质、氨基酸、DNA 脂质等反应。 它们与人体抗氧化系统,形成可逆的抗氧化防御,使人体生物大分子免受
氧化损伤。 提示人们养成好的膳食习惯,有利于提高生活质量。 |
| 关键词: ROS / RNS 疾病 抗氧化剂 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Advances in the Prevention of ROS/ RNS Oxidative Damage Diseases by Dietary Antioxidants |
|
REN Jian-min
|
|
School of Environment and Resources Chongqing Technology and Business University Chongqing 400067 China
|
| Abstract: |
| ROS / RNS is a product of normal human metabolism and has important physiological activities.
However high concentration of ROS / RNS produces oxidative stress leading to cancer cardiovascular and
pulmonary diseases hypertension neurodegeneration diabetes respiratory tract infection rheumatoid arthritis cataract and other oxidative damage diseases. In order to prevent diseases and promote health the sources of ROS/RNS in human body and the relationship between ROS / RNS and diseases were summarized based on a large number of literatures. Common dietary antioxidants such as phenolic compounds vitamin E carotenoids and vitamin C were introduced. The mechanism of scavenging free radicals and antioxidation by different antioxidant compounds was discussed. Phenolic compounds are widely found as antioxidant components of the human diet β-carotenoids are provitamin A and vitamin E are fat-soluble chain-breaking antioxidants that protect the integrity of cell membranes. Vitamin C is water-soluble and its free radical disproportionation rate is much higher than the reaction with other biological molecules such as proteins amino acids DNA etc. Together with the body's antioxidant system they form a reversible antioxidant defense to protect human biomacromolecules from oxidative damage. It is suggested that forming good dietary habits is beneficial to improve the quality of life. |
| Key words: ROS / RNS disease antioxidant |
