As a device connecting the car body and the wheel, the car suspension can effectively reduce the vibration caused by uneven road surface. In order to improve the car’s comfort and the stability of the operating system, based on the principle of magnetorheological damper and semi-active suspension system, we established the dynamic model of the magnetorheological damper semi-active suspension according to the system design of fuzzy control and by using Matlab/Simulink to build simulation model. Finally, the whole system is simulated under the random road surface, and the analysis shows that the fuzzy control has better vibration reduction effect and can better meet the requirements of suspension performance index.