In view of the problems existing in the water resources system in the Karst region,the entropy weight factor analysis method is used to analyze the main influencing factors of the water resources system in the Karst region,and the diagnosis and analysis of the water resources system in the Karst region are carried out through the comprehensive score results. The results show that the main influencing factors in Karst area are human activities,water quantity and water resources vulnerability. From the perspective of inter-annual changes,the whole state of water resources system in Karst region expresses good development trend in the fluchuation as a whole, among which the water resources system state in 2001,2003 and 2006 was relatively low,and the water resources system state in 2014 and 2015 was relatively high,and the water resources system state was obviously improved. It can be seen that the economic development mode under human activities,the protection of environment and ecology,and the improvement of basic water conservancy facilities are the premise to ensure the safe utilization of water resources in Karst areas,and can be conducive to actively coping with the impact of abnormal climate change on the amount of water resources.