| 引用本文: | 訾成方 1,高旭1,2,黄磊 3,甘秀梅 1,张怡昕 1.重庆主城区PhACs消耗的质量估算(J/M/D/N,J:杂志，M：书，D：论文，N：报纸).期刊名称,2014，31（11）：84-88 |
| CHEN X. Adap tive slidingmode contr ol for discrete2ti me multi2inputmulti2 out put systems[ J ]. Aut omatica, 2006, 42(6): 4272-435 |
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| 摘要: |
| 运用固相萃取（SPE），高效液相色谱/串联质谱法（HPLC-MS/MS）技术检测了西南地区最大污水处理厂，重庆市鸡冠石污水厂进水中磺胺类、大环内脂类、喹诺酮类抗生素、止痛消炎类、抗癫痫类等8类21种PhACs（医药活性物质）的含量水平；采用污水厂进水中PhACs，并考虑人体内药物代谢动力学，以推算重庆地区的药物消耗量；推算出的氧氟沙星用量与实际用量能较好地吻合（相似度72.5%），但是PhACs的反推算用量需要更进一步地核实；通常所选抗生素的进水质量负荷和推算得出的人均消耗水平与发达国家报道的水平相当或者 |
| 关键词: PhACs 污水 药物消耗反推算 |
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| Quality Estimation for the Consumption of Pharmaceutically Active Compounds (PhACs) in Main Districts of Chongqing |
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ZI Cheng-fang1, GAO Xu1,2, HUANG Lei3, GAN Xiu-mei1, ZHANG Yi-xin1
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| Abstract: |
| The contents of 21 kinds of PhACs in 8 classes drugs such as sulfanilamide type, macrolide type, carbostyril type, anti-pain and anti-inflammation type, anti-epileptic type and so on in the influent water of Chongqing Jiguanshi Waste Water Treatment Plant, the biggest waste water treatment plant in southwest area of China, were technically detected by solid-phase extraction method, high performance liquid chromatography/tandem mass spectrometry. The consumption quantity of these drugs in Chongqing is calculated by taking the advantage of the amount of PhACs in the influent water of this Plant and by considering pharmacokinetics in human body, for example, the usage of Ofloxacin is well consistent with the practical usage (similarity degree 72.5 percent), however, the reverse-calculation usage of PhACs needs to be further confirmed. Usually, the influent water mass load of the selected antibiotics is similar or a little higher than the reported per capita consumption level in developed countries but the target PhACS of other types are on the contrary of this result. |
| Key words: PhACs waste water reverse-calculation of drug consumption |
