The opening-up platform bears the implementation of China's major strategic objectives and tasks, and is an important carrier for China to promote economic system reform. Since the reform and opening-up, the construction of China’s platform has realized the transformation from initially integrating into the global market by expanding exports to promoting the high-level open development, and China emerged as to become a world trade power. In this context, the functional orientation of China’s opening-up platform has also realized the transformation from supporting export-oriented economic development to exploring an institutional opening system and building a new pattern of opening up and development. With China’s active exploration in trade, investment, industry, technology, and other aspects as well as the advancement of various economic system reforms, the opening-up platform has gone through a phase from a “Special Export Zone” with a single function and two external ends to a “Free Trade Test Zone” carrying the function of system innovation and exploring system-based opening-up. This has created a new pilot field for deepening reform and opening up in the new era. This paper argues that in order to promote the development of China’s domestic industries, upgrade the status of the international division of labor and change the mode of trade development, China’s development strategy has mainly experienced the transformation of import substitution, export orientation, and high-level openness. Correspondingly, the construction of the open platform has also achieved the practical logic transformation of partial opening, comprehensive opening, and institutional opening. In the stage of import substitution, China’s overall dependence on foreign trade is at a relatively low level and has undergone a significant decline and bottoming-out process, with limited participation in the international division of labor. Driven by the export-oriented strategy, China’s dependence on imports and exports has continued to rise, reaching a high point and then turning back, largely reflecting the impact of China’s comparative advantage transformation, changes in the international division of labor status, and external demand shocks. In the high-level opening-up stage, China’s dependence on foreign trade has continued to decline, reaching a low point and then turning to rise, reflecting the phased results of China’s acceleration in promoting the transformation and upgrading of foreign trade structure and enhancing trade competitiveness. The evolution of China’s trade policy and the spatial choice of the construction of the opening-up platform have had a profound impact on China's regional industrial development and regional economic growth, which has led to the differentiation of regional economic growth drivers, the initial formation of a multi-center network spatial growth pattern, and China's foreign trade model from the homogeneous competition and trade substitution to double circulation. It fully reflects the characteristics of inclusiveness, win-win and coordinated development of the Chinese path to modernization. In previous studies, scholars mostly focused on the logical sorting and empirical analysis of the specific opening-up platform. Research on the theory and practical logic of China’s opening-up platform construction in combination with the international economic and trade development environment and domestic opening development goals is rare. The innovation of this study is mainly reflected in three aspects: firstly, it systematically combs the development process and practical logic transformation of China's opening-up platform construction; secondly, focusing on the transformation of development strategy, it theoretically analyzes the evolution of trade mode and spatial impact of the construction of the opening-up platform; the third is to analyze the policy optimization of building a high-level opening-up platform in the future, providing a reference for China to promote the high-quality opening-up development of the platform in the new stage.