High-quality life is a state of the survival and development expressed by the people for sharing high-quality material life and spiritual life under the sufficiently balanced development condition of economy, politics, culture, society, ecology and so on, therefore, the creation of high-quality life is consistent with high-quality development and the increasing demand of the people for beautiful life. Based on three-dimension such as “happiness perception”, “safety perception” and “identification degree”, the perception evaluation index system of Chongqing Inhabitants for high-quality life is established, the sampling survey and analysis results from Chongqing Inhabitants adequately reflect the contradiction between the presently increasing demand of Chongqing Inhabitants for beautiful life and the unbalanced and insufficient development. Chongqing Inhabitants’ overall satisfaction with high-quality life stays at middle level, among which the index of “safety perception” and “happiness perception” is higher while the index of “identification degree” is lower, the satisfaction of the Inhabitants in the main urban districts and the Inhabitants with high income is higher. The relative backward economic development is the main reason for the acquisition perception (identification degree) of Chongqing Inhabitants to be lower, but they are fully confident and expectant for future material life and development. The satisfaction of Chongqing Inhabitants with the personal physical and asset safety as well as public order is high, but their satisfaction with food safety is low. The creation of high-quality life in Chongqing should firstly realize the high-quality development of the economy to boost the income growth and employment stability of Chongqing Inhabitants, then accelerate the economic and social development in the relative backward areas, strengthen the living security and support for the vulnerable groups and low income people, finally, intensify the construction of spiritual civilization and ecological civilization, and sufficiently take the development opportunity of constructing “Chengdu-Chongqing Economic Circle” to continuously promote the happiness perception, safety perception and acquisition perception of all Chongqing Inhabitants.