Current international economic order expresses obvious liberalism feature, from the perspective of historic evolution, strong western countries will periodically prefer the protectionism from the liberalism in order to protect their own interests, however, from long-run, the liberalism will still be the keynote of international economic order. Presently, that the United States deviates from international economic order of liberalism is contradicting, it shows that the United States is actively seeking new economic and trade cooperation while initiating trade disputes in the world, and its essence is to rebalance the interests under the action of the comprehensive factors such as political cycle, the rise of emerging countries, the change of development environment and so on. Under this background, the Sino-US trade friction will be a long-term repeated process, furthermore, the global COVID-19 epidemic further aggravates the uncertainty of Sino-US economic and trade relation. Future global economy will demonstrate pluralistic, multi-layer and compound pattern. Facing complex international economic situation, China should not only deal with Sino-US trade friction but also make top design for international economic order, make China’s plan, actively maintain the stable operation of global economy under multilateral framework of economic and trade system by taking “community of human destiny” as development concept and by taking the construction of “the Belt and Road” as practical basis, and boost the upgrading of international economic order toward cooperation and win-win through the reform of international trade and financial system.