Cross-border tourism is one of tourism products with influence and development potential, and the exploitation and development of cross-border tourism can boost the tourism development and economic growth of border regions. Through the study of different types of cross-border tourism route(CBTR) in Europe and Africa, such as hiking, bicycle and safari, this paper finds that CBTR needs to construct stable and reliable mutual funds security mechanism, to form united and coordinated management operation mechanism, to have efficient and convenient free pass visa system, and to emphasize harmonious paragenesis tourist experience with green and environment protection. Based on international experience, China should use openness and cooperation to boost the breakthrough of border tourism, actively promote CBTR exploitation and construction, use mechanism innovation to build high quality CBTR, build effective and mutual investment, coordinative management, convenient border-pass system and operation mechanism, use green and safe tourism to realize CBTR sustainable development and really protect ecological environment and tourists safety.