Three-change Reform provides active attempts for activating subject, activating factors, activating market and boosting rural industry. This paper summarizes the background, contents and operation model of Three-change Reform in Liupanshui rural areas of Guizhou Province, and based on that, proposes scientific master of the experience and successful condition of the Reform and absorbing the essence of the systematic advantage, in the future, in order to further perfect the Reform, there are some post-work to do such as the perfection of innovative and entrepreneurship environment, the optimization of the mechanism for the training and cultivation of new-style business subjects and the leaders, consolidation of infrastructure and public service facility construction, the highlighting of market-marketing network and brand service, the guidance of rural service industry and agricultural productive service industry in specialized, scaled, intensive and network development, the boosting of rural industry integration and green development, construction of property right and factor flowing platform, the promotion of system and standardization of the Three-change Reform, intensifying peasant training, and the cultivating of peasants ability to participate in industrial development, entrepreneurship and employment.