This paper firstly summarizes the mechanism that participating in the global value chain affects wages of manufacturing workers, then based on China Customs statistics data and China Family Panel Studies（CFPS）, uses the Heckman two-step selection model from the individual microcosmic level to empirically test the effect of China’s participating in global value chains on the wages of workers in manufacturing industries. The test results show that the deepening of the participation in the global value chain will significantly reduce the wages of manufacturing workers, after the robustness test from multiple perspectives, the conclusion is still valid. Further research finds that the participation in the global value chain is more obvious in wage inhibition for high-skilled workers, unproductive workers, workers in foreign-funded enterprises and workers in the central and eastern regions. The above findings have confirmed that China’s global value chain mainly conducts the micro-profit processing, assembly links, and is faced with the dilemma of low-end lock.