E-commerce cross-border runs express in order to get rid of the express restriction. Meanwhile, express cross-border runs e-commerce in order to open a new source of profits. It becomes a “New Normalcy” for the online shopping. The cooperation-competition relationship between e-commerce and express provides the theory foundation for cross-border business, but they also face many risks and challenges in reality. Cross-border operation may not be the best choice for e-commerce and express. Different enterprises should use different mode for cross-board business according to their own situation. At present, online shopping maintains good momentum of development, and cross-border operation between e-commerce and express would continue for a certain time. But industry shuffle between e-commerce and express is the trend, and cross-border operation will become integrated finally.