Based on urban and rural integrated medical insurance reform, the medical insurance of Zhanjiang for a serious disease uses the model by combining commercial insurance and social security, manages the medical insurance for a serious disease via the cooperation between commercial healthy insurance agencies and governmental departments, significantly decreases the proportion of “disastrous medical expenditure” in urban and rural residents, which is of ubiquitous reference significance by playing a role in mutual management and mutually taking the risk as well as the division of labor between the governments and commercial insurance agencies via letting the policies and ideas of market mechanism provide the medical insurance for urban and rural residents. The “single-type” economic compensation standard of “Zhanjiang Model” for a serious disease in medical insurance is paradox to the fairness, and the principle for “he medical insurance for serious diseases and high cost in hospitalized payment” does not reflect the essence of “the risk of serious diseases”, small medical cost gap and insufficient participation degree and extension of commercial insurance agencies. The medical insurance for a serious disease is “special beneficial type” insurance system, its insurance level should befit the economic and social development level, overall consider the risk and loss for a serious disease, evaluate in classification the bearing ability for a serious disease of a family, bring the management duty of commercial insurance agencies for a serious disease into fully play, and implement different compensation standards according to the serious degree of the risk and loss for a serious disease in order to avoid “disastrous medical expenditure” for a family.