From the perspective of basic resources，this paper elaborates competitive advantage of China’s tourism industry，constructs extensive resources set of tourism industry，uses Delphi method to reveal 21 relative success factors of China’s tourism industry operation management，builds six-layer ISM model such as the first basic layer including government management policy，service and management innovation capacity，natural condition and geographic condition，which has the most key influence on the realization of operation management objective of tourism industry，the exploitation rate of infrastructure and facilities，price level，the strategic matching of organization agencies，supply chain management capacity，financial management capacity，and new market development capacity belong to the other five layers，which have direct influence on the realization of operation strategy objective of tourism industry but which are not key influence factors. By using method-objective chain method，this paper distinguishes five key success factors of operation management of tourism industry such as governmental management policy，service and management innovation capacity， natural geographic condition，human resources exploitation and management capacity，service capacity and service quality. China should grasp the five key factors，realize the path optimization of operation management of China’s tourism industry，raise tourism industry operation efficiency，attain the strategic objective of the operation，and push forward the restructure and upgrading of China’s tourism industry.