Less-developed regional innovation theory is used to summarize Yubei Model of regional innovation driven by opening to outside world, this model has such prominent characteristics as expanding export by opening to outside world and to other provinces, developing specific modern industrial clusters by actively cooperating with Chongqing metropolitan industries and by actively accepting advanced industrial transfer from costal areas and from other countries, importing relatively advanced primary factors through opening to outside world and creating conditions for importing and developing in time advanced production factors, constructing necessary infrastructure to further promote environment quality through opening to outside world, connecting core areas of downtown to construct modern city with comprehensive urban function and specialized small towns with modern industrial function, reforming social and organizational cells to set up new-style regional government, enterprises, social units, families and so on fitting for economic and social transition, establishing diversified land transfer mechanism, continuously reforming family enterprises and setting up modern enterprise system, cultivating adequate factor market and reforming administrative system on time, continuing to change ideas and liberate ideology by firstly cultivating central towns and developing industries and commerce based on managing villages and traditional agriculture, then developing emerging urban areas and advanced industries, finally constructing the First Gateway Opening to Outside World in Chongqing.