Based on the comparative research on the development of three urban agglomerates in the middle areas of China from the general development level, urbanization level, urban scale structure, industrial structure, industrial efficiency, the structure of manufacturing and service sectors and so on, this paper proves that the developing quality of Chang - Zhu - Tan Urban Agglomerates are the best among the three urban agglomerates, Wuhan and Middle Plain Urban Agglomerate take the second place, while the scale of Wuhan and Middle Plain Urban Agglomerate is bigger and the impact of their development trends on the whole middle areas of China is larger. In the future, the rise of middle areas of China can be realized by implementing the strategy of using urban agglomerates to drive the economic development and differentiated development strategies depending on self- characteristics of the three urban agglomerates in the middle areas of China should be carried out.