The chemical industry in the Yangtze River Economic Belt plays an important role in the development of the national chemical industry. Among the 11 provinces along the Yangtze River Economic Belt, the chemical industry in Hubei Province and Jiangsu Province ranks in the forefront. However, while the chemical industry is undergoing rapid development, the problem of “chemical industry encircling the river” has become increasingly prominent. Hubei Province and Jiangsu Province have promulgated and implemented a series of plans and policies to guide the transformation and upgrading of the chemical industry to high-quality development, and thus become the typical examples for solving the problem of “chemical industry encircling the river”. Through the comparative analysis of “Hubei sample” and “Jiangsu sample”, the enlightenment of solving the problem of "chemical industry encircling the river" is arrived. Firstly, the scientific concept is used to guide the green development of the chemical industry. Secondly, plans are set up to creatively develop the chemical industry. And the support of policy is also vital for ensuring healthy development of the chemical industry.