Since the launch of the “Belt and Road” initiative, the international society is extensively and actively responded, and more than 100 countries have signed cooperation agreements with China. A lot of participating countries cover extensive regions and make China’s economic and trade cooperation with the countries along the “Belt and Road” have difference with different countries and express regional feature. This paper divides 137 sample participating countries into 10 regions such as East Asia, West Asia, South Asia, Central Asia, Oceania, Latin America, Central and Eastern Europe, South Europe, South Sahara African region and other Africa regions, and uses GTAP 10.0 database and CGE model to simulate the trade and economic effect produced by tariff reciprocation between China and each region. The simulation results show that the reciprocal tariff makes import and export trade and GDP obvious grow in China and the corresponding regions, although the trade prerequisite of such six regions as South Asia, South Sahara Africa, other Africa regions, Latin America, West Asia and Central Asia declines, only the welfare of South Asia declines. The regional reciprocal tariff between China and the regions with big scale trade can receive more benefit, the absolute benefit (GDP growth and welfare growth) of the reciprocal tariff between China and participating regions is correlated with their economic quantity and trade scale with China, however, the relative benefit (GDP growth) demonstrates the trend of bigger economic growth extent in the regions with lower economic development level (per capita GDP). “The unimpeded trade” really boosted the interactive benefit and double win in China and the participating countries and regions, this kind of interactive benefit and double win tends to be strengthened but has significant regional difference. Therefore, China should use different strategies based on different features of the regions and the countries while actively promoting the economic and trade cooperation between China and “the Belt and Road”.