As the core area of the Upper Reaches of the Yangtze River, the essence of Sichuan, Chongqing and Guizhou Integrated Development is the integrated development of the regions at the Upper Reaches of the Yangtze River. The strategic goal includes such two aspects as building the global level city group based on Chengdu-Chongqing city group and building the global level leading industries and enterprises groups. The strategic significance aims to greatly mitigate the contradiction between unbalanced and insufficient development of China and Chinese pursuit of happy life, to take the lead to boost the integrated development of the regions at the Upper Reaches of the Yangtze River, to help accelerate to attain the goal of the Belt and Road and The Yangtze River Economic Belt and so on, to help protect water resources and build ecological defence at the Upper Reaches of the Yangtze River, and to build a long-range and stable strategic rear area of China. The integrated development contents contain such five perspectives as integrated transportation and communication, integrated industrial development, integrated supervision and production factors, integrated ecological environment and integrated identity regulation for population flowing.